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Purity:99%
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Uses |
(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one can be used for synthetic preparation for asymmetric synthesis of dibenzoyl fluoro methyl-D-ribono-γ-lactone via asymmetric aldol condensation and enzymic hydrolysis from isopropylidene-D-glyceraldehyde and Et fluoropropionate. |
The present disclosure is directed towar...
The invention discloses a method for pre...
The invention discloses a preparation me...
A novel process for the preparation of l...
(4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide
(3R,4R,5R)-3?fluoro?4?hydroxy?5?(hydroxymethyl)?3?methyltetrahydrofuran?2?one
| Conditions | Yield |
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(4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide; With triethylamine tris(hydrogen fluoride); In dichloromethane; at 90 ℃; for 3h;
With hydrogenchloride; barium(II) chloride; In dichloromethane; at 50 ℃; for 5h; Solvent; Temperature; Concentration;
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89% |
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Multi-step reaction with 2 steps
1.1: tetraethylammonium fluoride / 1,4-dioxane / 16 h / 120 °C
1.2: 3 h / 20 °C
2.1: water; hydrogenchloride / ethanol / 48 h / 20 °C
With hydrogenchloride; water; tetraethylammonium fluoride; In 1,4-dioxane; ethanol;
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Multi-step reaction with 2 steps
1.1: triethylamine tris(hydrogen fluoride) / 2 h / 82 - 85 °C
2.1: hydrogenchloride / 0.5 h / 90 - 92 °C
2.2: 4 h
With hydrogenchloride; triethylamine tris(hydrogen fluoride);
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Multi-step reaction with 2 steps
1: tetraethylammonium fluoride / 1,4-dioxane / 16 h / 120 °C
2: hydrogenchloride / ethanol; water / 48 h / 20 °C
With hydrogenchloride; tetraethylammonium fluoride; In 1,4-dioxane; ethanol; water;
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(2R,3R,4R)-2-fluoro-4,5-O-isopropylidene-2-methyl-3-sulfooxy-3,4,5-thydroxypentanoic acid ethyl ester tetrabutylammoniun salt
(3R,4R,5R)-3?fluoro?4?hydroxy?5?(hydroxymethyl)?3?methyltetrahydrofuran?2?one
| Conditions | Yield |
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With trifluoroacetic acid; In water; acetonitrile; at 80 ℃; for 1.5h;
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100% |
C11H19FO5
(2S,3R)-3-[(4R)-2,2-dimethyl-[1,3]dioxolane-4-yl]-2,3-dihydroxy-2-methylpropionic acid ethyl ester
C10H18O6
(S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-benzyloxazolidin-2-one
((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate
(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate)
(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
C31H30FN5O5