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pd_meltingpoint:107.0 to 111.0 °C
Purity:99%
Pharmaceutical grade 877399-00-3 (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine in stock. Quality products make an important contribution to long-term revenue and profitability.
(R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is used in preparation of Crizotinib intermediate.
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-nitropyridine
![5-bromo-3-[1 (R)-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine](/upload/2023/5\ae86b518-4578-4de8-b410-438c41fecaf1.png)
5-bromo-3-[1 (R)-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine
| Conditions | Yield |
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Multi-step reaction with 2 steps
1: iron; acetic acid / ethanol / Inert atmosphere; Reflux
2: N-Bromosuccinimide / acetonitrile / 0 °C / Inert atmosphere
With N-Bromosuccinimide; iron; acetic acid; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1.1: hydrogen / methanol / 25 - 50 °C / Large scale reaction
2.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 1.42 h / -15 - -10 °C / Large scale reaction
2.2: 0.17 h / 0 °C / Large scale reaction
2.3: 0.25 h / Large scale reaction
With N-Bromosuccinimide; hydrogen; In methanol; dichloromethane; acetonitrile;
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Multi-step reaction with 2 steps
1: iron; hydrogenchloride / ethanol / 2.5 h / 90 °C
2: N-Bromosuccinimide / acetonitrile / 1.33 h / 0 °C
With hydrogenchloride; N-Bromosuccinimide; iron; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1: ethanol; iron / 0.33 h / 90 °C
2: N-Bromosuccinimide / acetonitrile / 1.33 h / 0 °C
With N-Bromosuccinimide; ethanol; iron; In acetonitrile;
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Multi-step reaction with 2 steps
1: hydrogenchloride; iron / ethanol / 2.58 h / 90 °C
2: N-Bromosuccinimide / acetonitrile / 1.33 h / 0 °C
With hydrogenchloride; N-Bromosuccinimide; iron; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1: hydrogenchloride; iron / ethanol / 12 h / 0 °C
2: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C
With hydrogenchloride; N-Bromosuccinimide; iron; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1: hydrogen / methanol / 48 h / 20 °C / 1292.09 - 3040.2 Torr
2: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.25 h / -10 - 20 °C
With N-Bromosuccinimide; hydrogen; In methanol; dichloromethane; acetonitrile;
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Multi-step reaction with 2 steps
1.1: iron / ethanol / 0.33 h / 90 °C
1.2: 2.25 h / 90 °C
2.1: N-Bromosuccinimide / acetonitrile / 1.33 h / 0 °C
With N-Bromosuccinimide; iron; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1: hydrogen / ethanol / 50 °C / 11251.1 Torr / Autoclave
2: N-Bromosuccinimide / acetonitrile / 0.5 h / -15 - 10 °C
With N-Bromosuccinimide; hydrogen; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1: acetic acid; iron / ethanol / 0.5 h / 40 - 60 °C
2: N-Bromosuccinimide / tetrachloromethane / 0 °C
With N-Bromosuccinimide; iron; acetic acid; In tetrachloromethane; ethanol;
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Multi-step reaction with 2 steps
1: hydrogenchloride; iron / ethanol; water / 12 h / 0 °C / Reflux
2: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C
With hydrogenchloride; N-Bromosuccinimide; iron; In ethanol; water; acetonitrile;
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Multi-step reaction with 2 steps
1.1: iron / ethanol / 0.58 h / 90 °C
1.2: 2 h / 90 °C
2.1: N-Bromosuccinimide / acetonitrile / 1.33 h / 0 °C
With N-Bromosuccinimide; iron; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1: acetic acid; iron / ethanol / 5 h / 20 °C / Large scale
2: N-Bromosuccinimide / dichloromethane; acetonitrile / 1 h / -15 - -10 °C / Large scale
With N-Bromosuccinimide; iron; acetic acid; In ethanol; dichloromethane; acetonitrile;
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Multi-step reaction with 2 steps
1: hydrogen; 3% Pd/silica / tetrahydrofuran / 20 °C / 3750.38 Torr
2: magnesium bromide; dipotassium peroxodisulfate / acetonitrile; water / 25 °C
With dipotassium peroxodisulfate; 3% Pd/silica; hydrogen; magnesium bromide; In tetrahydrofuran; water; acetonitrile;
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Multi-step reaction with 2 steps
1: iron; hydrogenchloride / ethanol; water / 12 h / Reflux
2: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C
With hydrogenchloride; N-Bromosuccinimide; iron; In ethanol; water; acetonitrile;
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Multi-step reaction with 2 steps
1: iron; acetic acid / ethanol / 2 h / Reflux
2: N-Bromosuccinimide / acetonitrile; dichloromethane / 0.25 h / Cooling with ice
With N-Bromosuccinimide; iron; acetic acid; In ethanol; dichloromethane; acetonitrile;
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Multi-step reaction with 2 steps
1: acetic acid; iron / ethanol / 1 h / 90 °C
2: N-Bromosuccinimide / acetonitrile / 0.17 h / 0 °C
With N-Bromosuccinimide; iron; acetic acid; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1: acetic acid; iron / ethanol / 1 h / 90 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 0.17 h / 0 °C / Inert atmosphere
With N-Bromosuccinimide; iron; acetic acid; In ethanol; acetonitrile;
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Multi-step reaction with 2 steps
1.1: hydrogen / methanol; dichloromethane / 0 h / 20 - 50 °C / 5400.54 - 6225.62 Torr / Flow reactor
2.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.5 h / 0 - 25 °C
2.2: 1 h / 25 °C
With N-Bromosuccinimide; hydrogen; In methanol; dichloromethane; acetonitrile;
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Multi-step reaction with 2 steps
1: acetic acid; iron / ethanol / 1 h / 40 - 60 °C
2: N-Bromosuccinimide / dichloromethane; acetonitrile / 1 h / -5 °C
With N-Bromosuccinimide; iron; acetic acid; In ethanol; dichloromethane; acetonitrile;
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5-bromopyridine-3-ol
(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine
| Conditions | Yield |
|---|---|
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Multi-step reaction with 3 steps
1.1: sulfuric acid / 0.5 h / Cooling with ice
1.2: 10 h / 20 °C / Cooling with ice
2.1: triphenylphosphine / tetrahydrofuran / 0.5 h / Cooling with ice
2.2: 4 h / 0 - 20 °C
3.1: iron; acetic acid / ethanol / 3 h / 78 °C
With sulfuric acid; iron; acetic acid; triphenylphosphine; In tetrahydrofuran; ethanol; 2.1: |Mitsunobu Displacement / 2.2: |Mitsunobu Displacement;
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The CAS number of (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is 877399-00-3.
More information of (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 877399-00-3 are:
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CAS Number |
877399-00-3 |
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Density |
1.643 |
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Melting Point |
107.0 to 111.0 °C |
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Boiling Point |
423.4±40.0 °C(Predicted) |
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HS CODE |
2933399090 |
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PSA |
48.14000 |
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LogP |
5.59340 |
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Pka |
5.55±0.10(Predicted) |
Synonyms for (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 877399-00-3:[5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine;
The chemical formula of (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is C13H10BrCl2FN2O which containing 1 Bromine atoms,1 Fluorine atoms and 1 Oxygen atoms,and the molecular weight of (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is 380.044.
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine can be used as a pharmaceutical intermediate.
Relevant articles related to (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine:
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Article |
Source |
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Novel pyridine derivatives having inhibition activity against SHIP2 and pharmaceutical compositions with the components |
- , (2020/10/03) |
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Preparation method of deuterated crizotinib and derivatives thereof |
- , (2020/12/31) |
Senova Pharma is a quality supplier of (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on pharmaceutical grade (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 877399-00-3.