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Purity:99%
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Chemical Properties |
White fine crystalline powder |
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Uses |
(S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL is a building block used in the synthesis of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. |
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Purification Methods |
Purify the alcohol by recrystallisation from Et2O/pet ether, Et2O, hexane [Balfe et al. J Chem Soc 797 1946, IR, NMR: Theisen & Heathcock J Org Chem 53 2374 1988, see also Fredga et al. Acta Chem Scand 11 1609 1957]. The RS-alcohol [57605-95-5] has m 63-65o, 65-66o from hexane. [Beilstein 6 III 3034, 6 IV 4346.] |
InChI:InChI=1/C12H12O/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-9,13H,1H3/t9-/m0/s1
Helically chiral poly(quinoxaline-2,3-di...
A nonenzymatic dynamic kinetic resolutio...
The invention discloses a tridentate nit...
Deracemization of racemic chiral compoun...
1-vinylnaphthalene
2-naphthaleneethanol
(S)-1-(1-Naphthyl)ethanol
(R)-1-(naphth-1-yl)ethanol
| Conditions | Yield |
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1-vinylnaphthalene; With benzo[1,3,2]dioxaborole; rhodium complex 2; In toluene; at 20 ℃; for 2h;
With sodium hydroxide; water; dihydrogen peroxide; In toluene; at 20 ℃; for 2h; Title compound not separated from byproducts;
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1-(1-naphthyl)ethanol
1'-naphthacetophenone
(S)-1-(1-Naphthyl)ethanol
(R)-1-(naphth-1-yl)ethanol
| Conditions | Yield |
|---|---|
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With (1R)-N-oxyl-1-(N-benzylcarbamoyl)-8-azabicyclo[3.2.1]octane; sodium hydrogencarbonate; sodium bromide; In dichloromethane; water; at 0 ℃; optical yield given as %ee; enantioselective reaction; Electrochemical reaction;
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62% |
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With palladium dichloro (η-2,5-norbornadiene); oxygen; (-)-sparteine; In toluene; at 80 ℃; for 192h; Title compound not separated from byproducts;
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54% |
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With 3 A molecular sieve; oxygen; (-)-sparteine; palladium dichloro (η-2,5-norbornadiene); In toluene; at 80 ℃; for 192h; under 760 Torr;
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54% |
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With Na-Pi buffer; In acetone; for 48h; Yields of byproduct given. Title compound not separated from byproducts; tubers of Solanum tuberosum cv. Saturna, pH 5.9; other biologically active material: tubers of Helianthus tuberosus;
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10 % Chromat. |
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With 3 A molecular sieve; oxygen; caesium carbonate; (R)-H8-1,1'-binaphthalenyl-2,2'-diamine-based Pd(II); In toluene; at 80 ℃; for 48h; under 760 Torr;
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With oxygen; potassium carbonate; heptakis(6-amino-6-deoxy)-β-cyclodextrin; In tetrahydrofuran; water; at 29.84 ℃; for 48h; enantioselective reaction; Resolution of racemate;
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1'-naphthacetophenone
2,2,2-trichloroethyl butyrate
1-(1-naphthyl)ethanol
1-ethylnapthelene
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-(4-bromophenyl)butyrate
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate
1-acetonaphthone 2,4-dinitrophenylhydrazone
1'-naphthacetophenone