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Purity:99%
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Chemical Properties |
White solid |
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Uses |
Aprepitant intermediate. |
InChI:InChI=1/C10H8F6O/c1-5(17)6-2-7(9(11,12)13)4-8(3-6)10(14,15)16/h2-5,17H,1H3/t5-/m0/s1
The ratio of substrate to catalyst (S/C)...
Most ligands applied for asymmetric hydr...
A nonenzymatic dynamic kinetic resolutio...
The invention discloses a tridentate nit...
Enzymatic reactions through mononuclear ...
vinyl acetate
1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol
(R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol
(S)-3,5-bis(trifluoromethyl)-1-phenylethanol
| Conditions | Yield |
|---|---|
|
With novozyme-435; In diethyl ether; at 20 ℃; for 84h; Resolution of racemate; Enzymatic reaction;
|
44.6% 48.9% |
|
With Novozyme-435 lipase; In tetrahydrofuran; at 20 ℃; for 72h; Resolution of racemate; Enzymatic reaction;
|
43% 41% |
|
With 2,6-dimethylpyridine; lipase CAL-B; In toluene; at 40 ℃; for 68h;
|
5.5 g |
vinyl acetate
1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol
(R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol
(S)-3,5-bis(trifluoromethyl)-1-phenylethanol
![(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol](/upload/2023/5\09933498-048e-4a76-a005-6407ad19ff52.png)
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
| Conditions | Yield |
|---|---|
|
With Novozyme-435 lipase; In tetrahydrofuran; at 20 ℃; for 72h; Resolution of racemate; Enzymatic reaction;
|
40% 89 % ee |
|
Candida antartica lipase B; In various solvent(s); at 40 ℃; for 2h; under 67505.4 Torr;
|
3,5-bis(trifluoromethyl)phenyl methyl ketone
3,5-Bis(trifluoromethyl)benzaldehyde
methyltriisopropoxytitanium(IV)
1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol
(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl-2,2,2-trichloroethanimidoate
methanesulfonic acid (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl ester
C17H16F6O3
(2R,3R,4S)-2-[(1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(3-bromo-4-fluorophenyl)-4-vinyltetrahydropyran