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110611-21-7

  • Product Name:(R)-1-(4-CHLOROPHENYL)-1-PROPANOL
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Product Details

Purity:99%

High Quality 110611-21-7 On Sale, (R)-1-(4-CHLOROPHENYL)-1-PROPANOL

  • Molecular Formula:C9H11ClO
  • Molecular Weight:170.639
  • Boiling Point:257.5±15.0 °C(Predicted) 
  • PKA:14.22±0.20(Predicted) 
  • PSA：20.23000 
  • Density:1.145±0.06 g/cm3(Predicted) 
  • LogP:2.78340 

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110611-21-7 Process route

1-(4-chlorophenyl)-1-propanol
13856-85-4

1-(4-chlorophenyl)-1-propanol

4'-chloropropiophenone
6285-05-8

4'-chloropropiophenone

(R)-1-(4-chlorophenyl)-1-propanol
110611-21-7

(R)-1-(4-chlorophenyl)-1-propanol

Conditions
Conditions Yield
With sulfuric acid; MnII((1R,2R)-N,N'-dimethyl-N,N'-bis((R)-(3,5-di-tert-butylphenyl)-2-pyridinylmethyl)cyclohexane-1,2-diamine)(OTf)2; dihydrogen peroxide; In water; acetonitrile; at 0 ℃; for 1h; Inert atmosphere; Schlenk technique;
90 % ee
diethylzinc
557-20-0

diethylzinc

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

(R)-1-(4-chlorophenyl)-1-propanol
110611-21-7

(R)-1-(4-chlorophenyl)-1-propanol

(S)-1-(4-chlorophenyl)-1-propanol
73890-73-0

(S)-1-(4-chlorophenyl)-1-propanol

para-Chlorobenzyl alcohol
873-76-7

para-Chlorobenzyl alcohol

Conditions
Conditions Yield
With (1S)-(+)-3-exo-(dimethylamino)isoborneol; In toluene; at 0 ℃; for 12h; Yields of byproduct given. Title compound not separated from byproducts;
2%
86%
With polymer-supported camphor derivative; In toluene; at 20 ℃; Title compound not separated from byproducts;
13%
With (P,P)-(+)-bis[5]helicene diol; In toluene; for 24h; Title compound not separated from byproducts;
 
With chiral bicyclo[3.2.1]octane-based alcohol; In hexane; toluene; at 20 ℃; for 24h; Title compound not separated from byproducts;
 
With (-)-8-(9H-fluoren-9-ylidene)-1-(2-hydroxyphenyl)-7-methyl-5,6,7,8-tetrahydronaphthalen-2-ol; In hexane; toluene; at 0 ℃; for 168h; enantioselective reaction; Schlenk technique; Inert atmosphere;
35 % ee
With (-)-8-(9H-fluoren-9-ylidene)-1-(2-hydroxyphenyl)-7-methyl-5,6,7,8-tetrahydronaphthalen-2-ol; In hexane; toluene; at 0 ℃; for 168h; enantioselective reaction; Schlenk technique; Inert atmosphere;
24 % ee

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