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Purity:99%
tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate(Cas 877399-74-1) is used in medicine.
InChI:InChI=1/C19H32BN3O4/c1-17(2,3)25-16(24)22-10-8-15(9-11-22)23-13-14(12-21-23)20-26-18(4,5)19(6,7)27-20/h12-13,15H,8-11H2,1-7H3
Bifunctional compounds formed by conjuga...
Disclosed herein is an aminopyrazine com...
The invention relates to a piperidine-co...
The present disclosure is directed to co...
tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate
bis(pinacol)diborane
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
| Conditions | Yield |
|---|---|
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
87.9% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
87.9% |
|
With potassium acetate; tetrakis(triphenylphosphine) palladium(0); In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
83% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; at 80 ℃; for 3h; Inert atmosphere;
|
83% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 3h; Inert atmosphere;
|
83% |
|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 3h; Inert atmosphere;
|
73% |
|
With 1,1′ bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 3.16h; Inert atmosphere;
|
73% |
|
tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 20 ℃; for 2h; Inert atmosphere;
bis(pinacol)diborane; In tetrahydrofuran; at 20 ℃; for 12h;
|
61.5% |
|
With potassium acetate; In dimethyl sulfoxide;
|
40% |
|
With potassium acetate; bis-triphenylphosphine-palladium(II) chloride; In dimethyl sulfoxide; at 80 ℃; for 2h;
|
40% |
|
With potassium acetate; bis-triphenylphosphine-palladium(II) chloride; In dimethyl sulfoxide; at 80 ℃; for 12h;
|
40% |
|
With potassium acetate; bis-triphenylphosphine-palladium(II) chloride; In dimethyl sulfoxide; at 80 ℃; for 2h;
|
40% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
40% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
40% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
40% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
40% |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h;
|
|
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 0.666667h; Sealed tube; Inert atmosphere;
|
155mg |
4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
bis(pinacol)diborane
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
| Conditions | Yield |
|---|---|
|
With C54H44NO2PPdS; potassium acetate; In tetrahydrofuran; at 80 ℃; for 24h; Inert atmosphere; Sealed tube;
|
94% |
|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;
|
90% |
|
With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 30 ℃; for 9h; Inert atmosphere; Large scale;
|
81% |
|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 0.166667h; Inert atmosphere;
|
44% |
|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;
|
|
|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;
|
5.4 g |
|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In N,N-dimethyl-formamide; at 80 ℃; for 10h; Inert atmosphere;
|
|
|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere;
|
5.4 g |
|
With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;
|
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate
tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate
bis(pinacol)diborane
4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
tert-butyl 4-(4-(4-(4-amino-2-fluorophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride
tert-butyl 4-(4-(7-(2-chlorophenyl)-6,7-dihydro-3H-benzo[f]pyrazolo[3,4-c]isoquinolin-1-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate