SENOVA PHARMA
- +86 185 8909 5435
- sales@senovaph.com
Your Location：Home >Products >Organic Chemistry >179688-53-0
pd_meltingpoint:293 °C
Purity:99%
Quality products make an important contribution to long-term revenue and profitability. Hot Sale Cosmetics Grade 179688-53-0 In Stock, In Bulk Supply with Fast Delivery.
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is an organic compound with potential biological activity. It belongs to the quinazoline family of organic molecules.
acetic anhydride
3H-6,7-dimethoxyquinazolin-4-one
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
| Conditions | Yield |
|---|---|
|
3H-6,7-dimethoxyquinazolin-4-one; With methanesulfonic acid; DL-methionine; at 120 ℃; for 24h;
acetic anhydride; With pyridine; at 100 ℃; for 22h;
|
87% |
|
With methanesulfonic acid; DL-methionine; Multistep reaction; 1.) 100 deg C, 3 h, 2.) Py;
|
acetic anhydride
6-hydroxy-7-methoxyquinazolin-4(3H)-one
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
| Conditions | Yield |
|---|---|
|
With pyridine; at 100 ℃; for 4h;
|
99% |
|
With pyridine; at 100 ℃; for 2h;
|
99% |
|
With pyridine; at 100 ℃; for 2h;
|
96.6% |
|
With pyridine; In N,N-dimethyl-formamide; at 40 - 45 ℃; for 1h;
|
96% |
|
With pyridine; at 100 ℃; for 4h;
|
93% |
|
With pyridine; at 100 ℃; for 4h;
|
93% |
|
In pyridine; at 116 ℃; for 3h;
|
82% |
|
at 120 - 125 ℃; for 3h;
|
75% |
|
With pyridine; at 100 ℃; for 6h;
|
74% |
|
In pyridine; Inert atmosphere;
|
62% |
|
With pyridine; dmap; at 100 ℃; for 4h;
|
60% |
|
With pyridine; at 100 ℃; for 4h;
|
53% |
|
With pyridine; at 20 - 100 ℃; for 3h;
|
53% |
|
With pyridine; at 100 ℃; for 3h;
|
53% |
|
With pyridine; at 100 ℃;
|
51% |
|
With pyridine; at 100 ℃; for 6h;
|
51% |
|
With pyridine; for 3h; Heating / reflux;
|
50% |
|
With pyridine; at 100 ℃; for 2h;
|
41.3% |
|
With pyridine; dmap; at 100 ℃; for 6h; Inert atmosphere;
|
40% |
|
With pyridine;
|
|
|
With pyridine; dmap; at 100 ℃; for 6h;
|
|
|
In pyridine; for 3h; Heating / reflux;
|
|
|
With pyridine; for 3h; Heating / reflux;
|
|
|
With pyridine; at 100 ℃; for 4h;
|
|
|
With pyridine; dmap; at 0 - 20 ℃; for 12h; Inert atmosphere;
|
|
|
With pyridine; dmap; at 100 ℃;
|
|
|
With dmap; In pyridine;
|
|
|
With pyridine; dmap; at 0 - 20 ℃; for 12h;
|
|
|
With pyridine; dmap; at 0 - 20 ℃; for 12h;
|
|
|
With pyridine; at 20 ℃;
|
|
|
With pyridine; for 3h; Heating / reflux;
|
|
|
acetic anhydride; 6-hydroxy-7-methoxyquinazolin-4(3H)-one; With pyridine; at 100 ℃; for 1h;
With dmap; for 5h;
|
|
|
With pyridine; In N,N-dimethyl-formamide; at 40 - 45 ℃; for 1h;
|
117 g |
|
With pyridine; Reflux;
|
The CAS number of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is 179688-53-0.
More information of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0 are:
|
CAS Number |
179688-53-0 |
| European Community (EC) Number | 808-050-2 |
| DSSTox Substance ID | DTXSID50621628 |
| Nikkaji Number | J2.697.315E |
| Canonical SMILES | CC(=O)OC1=C(C=C2C(=C1)C(=O)NC=N2)OC |
|
Density |
1.395 g/cm3 |
|
Melting Point |
293 °C |
|
Boiling Point |
390.518 °C at 760 mmHg |
|
Flash Point |
189.979 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.612 |
|
HS CODE |
2933990090 |
|
PSA |
81.28000 |
|
LogP |
0.85700 |
|
Pka |
0.67±0.20(Predicted) |
Synonyms for 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0:6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one;6-Acetoxy-7-methoxyquinazolin-4(3H)-one;6-Acetoxy-7-methoxyquinazolin-4-one;Acetic acid 4-hydroxy-7-methoxyquinazolin-6-yl ester;3,4-Dihydro-4-oxo-6-acetyloxy-7-methoxyquinazoline;4(1H)-Quinazolinone,6-(acetyloxy)-7-methoxy- (9CI);3,4-Dihydro-4-oxo-6-acetoxy-7-methoxyquinazoline;
The chemical formula of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is C11H10N2O4 which containing 11 Carbon atoms,10 Hydrogen atoms,2 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is 234.211.
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is commonly used in pharmaceutical research. It has been studied for its potential use in the treatment of various diseases, including cancer and inflammation. The compound's precise mechanism of action and therapeutic potential are still under investigation, and further research is needed to fully understand its pharmacological properties.
InChI:InChI=1/C11H10N2O4/c1-6(14)17-10-3-7-8(4-9(10)16-2)12-5-13-11(7)15/h3-5H,1-2H3,(H,12,13,15)
InChIKey:SOLQIFINSOHAQD-UHFFFAOYSA-N
Relevant articles related to 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate:
|
Article |
Source |
| Structure optimization and discovery of novel compound for the treatment of insertion mutations within exon 20 of EGFR and HER2 |
The mixture of 3,4-dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate (2.00 g, 8.05 mmol) and excess pyridine hydrochloride (55.8 g, 483 mmol) were heated at 120 ℃ for 4 h under Ar. … , Bioorganic & Medicinal Chemistry Volume 81, 1 March 2023, 117202 |
| Synthesis and antitumor activity of 3,4-dihydro-7-methoxy-4-oxoquinazoline-6-carboxamide derivatives. | Bioorg Med Chem. 2007;15(7):2728-2736. |
|
Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10 |
Li, Zhe,Huang, Yiyou,Wu, Yinuo,Chen, Jingyi,Wu, Deyan,Zhan, Chang-Guo,Luo, Hai-Bin , p. 2099 - 2111 (2019/02/26) |
| Synthesis and biological evaluation of novel 3,4-dihydro-7-methoxy-4-oxoquinazoline derivatives as potential anti-inflammatory agents. | Bioorg Med Chem Lett. 2019;29(17):2360-2364. |
Senova Pharma is a quality supplier of cosmetics grade 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate with fast delivery. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0.