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149809-43-8

  • Product Name:(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
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Product Details

Purity:99%

Top Purity 149809-43-8 (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Best Price

  • Molecular Formula:C21H21F2N3O4S
  • Molecular Weight:449.478
  • Vapor Pressure:9.85E-15mmHg at 25°C 
  • Melting Point:100-102°C 
  • Refractive Index:1.615 
  • Boiling Point:608.1 °C at 760 mmHg 
  • PKA:2.75±0.10(Predicted) 
  • Flash Point:321.6 °C 
  • PSA：91.69000 
  • Density:1.40 g/cm3 
  • LogP:4.28300 

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester(Cas 149809-43-8) Usage

Article

Source

Chemical Properties

White Crystalline Solid

Uses

Posaconazole intermediate. Antifungal agent.

InChI:InChI=1/C21H21F2N3O4S/c1-15-2-5-18(6-3-15)31(27,28)30-11-16-9-21(29-10-16,12-26-14-24-13-25-26)19-7-4-17(22)8-20(19)23/h2-8,13-14,16H,9-12H2,1H3/t16-,21-/m0/s1

149809-43-8 Relevant articles

Preparation method of posaconazole intermediate

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, (2021/11/21)

The invention relates to the technical f...

POSACONAZOLE, COMPOSITION, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USES THEREOF

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Paragraph 0246-0247, (2019/03/14)

The present invention relates to a compo...

Preparation method for preparing posaconazole midbody

-

, (2017/08/27)

The invention provides a method for prep...

IMPROVED PROCESS FOR THE PREPARATION OF ((3S,5R)-5-((1H-1,2,4-TRIAZOL-1-YL)METHYL)-5-(2,4-DIFLUOROPHENYL)TETRAHYDROFURAN-3-YL)METHYL-4-METHYLBENZENESULFONATE

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Page/Page column 22, (2015/05/06)

The present invention relates to process...

149809-43-8 Process route

C<sub>14</sub>H<sub>15</sub>F<sub>2</sub>N<sub>3</sub>O<sub>2</sub>*(x)ClH

C14H15F2N3O2*(x)ClH

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
149809-43-8

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

Conditions
Conditions Yield
C14H15F2N3O2*(x)ClH; With triethylamine; In dichloromethane; at 12 - 22 ℃; for 1h;
p-toluenesulfonyl chloride; With dmap; In dichloromethane; at 12 - 25 ℃; for 4h;
94%
C<sub>14</sub>H<sub>15</sub>F<sub>2</sub>N<sub>3</sub>O<sub>2</sub>*ClH
1350466-82-8

C14H15F2N3O2*ClH

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
149809-43-8

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

Conditions
Conditions Yield
With dmap; triethylamine; In dichloromethane; at 14 - 30 ℃;
94%

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